It doesn't matter the media, the darkness that you portray has to have root some where in it.

On another note, in Serenity/ Firefly, River Tam.

Her usual crazies aside (erm, the psychic thing) she has 'flashbacks' panic attacks etc as a result of the 'experiments' used on her.

I like looking at other media, painting etc and wondering what was in the artists mind when they drew/ painted them.

One for example is Edvard Munch's The Scream

http://en.wikipedia.org/wiki/The_Scream

This is a quote from Munch
The original German title given to the work by Munch was Der Schrei der Natur (The Scream of Nature).
In a note in his diary - the page headed Nice 22.01.1892, Munch described his inspiration for the image thus:
“I was walking along a path with two friends—the sun was setting—suddenly the sky turned blood red—I paused, feeling exhausted, and leaned on the fence—there was blood and tongues of fire above the blue-black fjord and the city—my friends walked on, and I stood there trembling with anxiety—and I sensed an infinite scream passing through nature.„ Edvard Munch