Welcome, Langdon.
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1) Is it possible/normal for someone with PTSD to be functional at work, but close off to the world when home?
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Yes. I do my job quite well, but I am a wreck at home. I call in sick if I know it's going to be a non-fuctional day. That said, it's impossible to know without more information whether this is the case with your friend. It may be that he struggled to be functional at work and that's why he had trouble with coworkers.
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Do you think this could be a form of self-harm?
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Could it be related to his trauma, as well? I have certainyl scratched myself until I bled as self-harm, to that is also a possibility.
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does it help the person with PTSD to know someone is thinking about them?
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It helps me immensely. You need to take care of yourself first, though, and decide how much reaching out you are willing and able to do when he is unable to reach back. If he is unable to connect with you, are you willing to keep trying? If so, to what end?
Good luck.