I'm on two anti-depressants, one anti-anxiety, Motrin for headaches, and as of last week, Lamictal for mood stabilizing, depression and irritability. I haven't found the combination to be numbing or anything that negative so far. I've actually seen improvement in myself and so has my psychologist. I also love exercise for its good affects, but it only works for me if I could do it all day long, which I can't :)