Meds have helped me battle the depression. The rest, well, they work sometimes but figuring out the right combination is very difficult. I think I've been on everything.

One thing I will say, you need to find a psychiatrist that will work with you and listen to you. As a team you can work up combinations based on your responses. Do drugs fix it - no, they just lower the thresholds of tolerance of symptoms.

I had a psychiatrist that was awesome, I weened myself off of all meds over a period of two months. He appreciated it and thought everyone should try it now and then to see what the baseline of symptoms are. I was impressed.
I lasted about 4 months before I hit rock bottom again with the depression.

When I returned to meds we then started with the Effexor and slowly added others as needed. Unfortunately I have a new psychiatrist and am still working on the ground work of the relationship. Some things I fill and others I set aside.