I suppose it depends what you mean by 'a drug that works'. I have tried many different drugs, but I'm yet to find one that "works", with regards to my depression. I don't know if this answer could be added to your poll. But although I'm trying to find help in other ways, through therapy, exercise and healthy eating etc, I'm struggling to find a drug that helps with my PTSD symptoms. I do have sleeping tablets that "works", and I have had anti-anxiety medication, in the past, that "works" in the short term. But over-all, nothing I have tried has really helped all my PTSD symptoms.
Sorry, if I'm over-analysing your question.