anthony
21-07-2006, 12:33 AM
Introduction
For all intensive purposes, this thread is not directly related to PTSD medication, but around PTSD medications, in that Lyrica is used for treatment of seizure disorders.
Suitability
Lyrica is only suitable to those who suffer seizure disorders, or those that are defined within the scope of acceptable risk for use.
Dosage
The recommended maximum dosage is 300mg per day, also being the perceived normal dosage of 3 x 100mg doses at intervals daily. In actual fact though, often dosage upto 600mg per day is used for more severe treatments.
Side Effects
All drugs have possible side effect/s, which need to be taken into consideration when being prescribed.
You have approximately a 1:3 chance of having any side effect/s with Lyrica from the clinical studies performed at 300mg per day. This figure increases to approximately 1:2.3 at 600mg per day.
Lyrica has the following possible side effects:
Body as a whole
Asthenia
Accidental injury
Back pain
Chest pain
Face edema
Infection
Headache
Pain
Accidental injury
Flu syndrome
Digestive system
Dry mouth
Constipation
Flatulence
Vomiting
Metabolic and nutritional disorders
Peripheral edema
Weight gain
Edema
Hypoglycemia
Musculoskeletal system
Myasthenia
Nervous system
Abnormal gait
Amnesia
Ataxia
Confusion
Dizziness
Euphoria
Incoordination
Nervousness
Neuropathy
Somnolence
Speech disorder
Thinking abnormala
Tremor
Vertigo
Respiratory system
Dyspnea
Bronchitis
Special senses
Blurry vision
Abnormal vision
Eye Disorder
Diplopia
Urogenital System
Urinary IncontinenceFurther categorization of possible side effects are listed in decreasing order:
Body as a Whole
Frequent: Abdominal pain, Allergic reaction, Fever;
Infrequent: Abscess, Cellulitis, Chills, Malaise, Neck rigidity, Overdose, Pelvic pain, Photosensitivity reaction, Suicide attempt;
Rare: Anaphylactoid reaction, Ascites, Granuloma, Hangover effect, Intentional Injury, Retroperitoneal Fibrosis, Shock, Suicide.Cardiovascular System
Infrequent: Deep thrombophlebitis, Heart failure, Hypotension, Postural hypotension, Retinal vascular disorder, Syncope;
Rare: ST Depressed, Ventricular Fibrillation.Digestive System
Frequent: Gastroenteritis, Increased appetite;
Infrequent: Cholecystitis, Cholelithiasis, Colitis, Dysphagia, Esophagitis, Gastritis, Gastrointestinal hemorrhage, Melena, Mouth ulceration, Pancreatitis, Rectal hemorrhage, Tongue edema;
Rare: Aphthous stomatitis, Esophageal Ulcer.Hemic and Lymphatic System
Frequent: Ecchymosis;
Infrequent: Anemia, Eosinophilia, Hypochromic anemia, Leukocytosis, Leukopenia, Lymphadenopathy, Thrombocytopenia;
Rare: Myelofibrosis, Polycythemia, Prothrombin decreased, Purpura, Thrombocythemia.Metabolic and Nutritional Disorders
Rare: Glucose Tolerance Decreased, Urate Crystalluria.Musculoskeletal System
Frequent: Arthralgia, Leg cramps, Myalgia, Myasthenia;
Infrequent: Arthrosis;
Rare: Generalized Spasm.Nervous System
Frequent: Anxiety, Depersonalization, Hypertonia, Hypesthesia, Libido decreased, Nystagmus, Paresthesia, Stupor, Twitching;
Infrequent: Abnormal dreams, Agitation, Apathy, Aphasia, Circumoral paresthesia, Dysarthria, Hallucinations, Hostility, Hyperalgesia, Hyperesthesia, Hyperkinesia, Hypokinesia, Hypotonia, Libido increased, Myoclonus, Neuralgia;
Rare: Addiction, Cerebellar syndrome, Cogwheel rigidity, Coma, Delirium, Delusions, Dysautonomia, Dyskinesia, Dystonia, Encephalopathy, Extrapyramidal syndrome, Guillain Barre syndrome, Hypalgesia, Intracranial hypertension, Manic reaction, Paranoid reaction, Peripheral neuritis, Psychotic depression, Schizophrenic reaction, Torticollis, Trismus.Respiratory System
Rare: Apnea, Atelectasis, Bronchiolitis, Hiccup, Laryngismus, Lung edema, Lung fibrosis, Yawn.Skin and Appendages
Frequent: Pruritus;
Infrequent: Alopecia, Dry skin, Eczema, Hirsutism, Skin ulcer, Urticaria, Vesiculobullous rash;
Rare: Angioedema, Exfoliative dermatitis, Lichenoid dermatitis, Melanosis, Petechial rash, Purpuric rash, Pustular rash, Skin atrophy, Skin necrosis, Skin nodule, Stevens-Johnson syndrome, Subcutaneous nodule.Special senses
Frequent: Conjunctivitis, Diplopia, Otitis media, Tinnitus;
Infrequent: Abnormality of accommodation, Blepharitis, Dry eyes, Eye hemorrhage, Hyperacusis, Photophobia, Retinal edema, Taste loss, Taste perversion;
Rare: Anisocoria, Blindness, Corneal ulcer, Exophthalmos, Extraocular palsy, Iritis, Keratitis, Keratoconjunctivitis, Miosis, Mydriasis, Night blindness, Ophthalmoplegia, Optic atrophy, Papilledema, Parosmia, Ptosis, UveitisUrogenital System
Frequent: Anorgasmia, Impotence, Urinary frequency, Urinary incontinence;
Infrequent: Abnormal ejaculation, Albuminuria, Amenorrhea, Dysmenorrhea, Dysuria, Hematuria, Kidney calculus, Leukorrhea, Menorrhagia, Metrorrhagia, Nephritis, Oliguria, Urinary retention;
Rare: Acute kidney failure, Balanitis, Bladder Neoplasm, Cervicitis, Dyspareunia, Epididymitis, Female lactation, GlomerulitisWarnings
Withdrawal of Antiepileptic Drugs (AEDs)
As with all AEDs, pregabalin should be withdrawn gradually to minimize the potential of increased seizure frequency in patients with seizure disorders. If pregabalin is discontinued this should be done gradually over a minimum of 1 week.
Read more from the fact sheets on Lyrica:
Lyrica Description (http://www.rxlist.com/cgi/generic4/lyrica.htm)
Lyrica Pharmacology (http://www.rxlist.com/cgi/generic4/lyrica_cp.htm)
Lyrica Dosage Information (http://www.rxlist.com/cgi/generic4/lyrica_ids.htm)
Lyrica Side Effects and Drug Interactions (http://www.rxlist.com/cgi/generic4/lyrica_ad.htm)
Lyrica Warnings and Precautions (http://www.rxlist.com/cgi/generic4/lyrica_wcp.htm)
Lyrica Overdose Information (http://www.rxlist.com/cgi/generic4/lyrica_od.htm)
Lyrica Patient Information (http://www.rxlist.com/cgi/generic4/lyrica_pi.htm)
For all intensive purposes, this thread is not directly related to PTSD medication, but around PTSD medications, in that Lyrica is used for treatment of seizure disorders.
Suitability
Lyrica is only suitable to those who suffer seizure disorders, or those that are defined within the scope of acceptable risk for use.
Dosage
The recommended maximum dosage is 300mg per day, also being the perceived normal dosage of 3 x 100mg doses at intervals daily. In actual fact though, often dosage upto 600mg per day is used for more severe treatments.
Side Effects
All drugs have possible side effect/s, which need to be taken into consideration when being prescribed.
You have approximately a 1:3 chance of having any side effect/s with Lyrica from the clinical studies performed at 300mg per day. This figure increases to approximately 1:2.3 at 600mg per day.
Lyrica has the following possible side effects:
Body as a whole
Asthenia
Accidental injury
Back pain
Chest pain
Face edema
Infection
Headache
Pain
Accidental injury
Flu syndrome
Digestive system
Dry mouth
Constipation
Flatulence
Vomiting
Metabolic and nutritional disorders
Peripheral edema
Weight gain
Edema
Hypoglycemia
Musculoskeletal system
Myasthenia
Nervous system
Abnormal gait
Amnesia
Ataxia
Confusion
Dizziness
Euphoria
Incoordination
Nervousness
Neuropathy
Somnolence
Speech disorder
Thinking abnormala
Tremor
Vertigo
Respiratory system
Dyspnea
Bronchitis
Special senses
Blurry vision
Abnormal vision
Eye Disorder
Diplopia
Urogenital System
Urinary IncontinenceFurther categorization of possible side effects are listed in decreasing order:
Body as a Whole
Frequent: Abdominal pain, Allergic reaction, Fever;
Infrequent: Abscess, Cellulitis, Chills, Malaise, Neck rigidity, Overdose, Pelvic pain, Photosensitivity reaction, Suicide attempt;
Rare: Anaphylactoid reaction, Ascites, Granuloma, Hangover effect, Intentional Injury, Retroperitoneal Fibrosis, Shock, Suicide.Cardiovascular System
Infrequent: Deep thrombophlebitis, Heart failure, Hypotension, Postural hypotension, Retinal vascular disorder, Syncope;
Rare: ST Depressed, Ventricular Fibrillation.Digestive System
Frequent: Gastroenteritis, Increased appetite;
Infrequent: Cholecystitis, Cholelithiasis, Colitis, Dysphagia, Esophagitis, Gastritis, Gastrointestinal hemorrhage, Melena, Mouth ulceration, Pancreatitis, Rectal hemorrhage, Tongue edema;
Rare: Aphthous stomatitis, Esophageal Ulcer.Hemic and Lymphatic System
Frequent: Ecchymosis;
Infrequent: Anemia, Eosinophilia, Hypochromic anemia, Leukocytosis, Leukopenia, Lymphadenopathy, Thrombocytopenia;
Rare: Myelofibrosis, Polycythemia, Prothrombin decreased, Purpura, Thrombocythemia.Metabolic and Nutritional Disorders
Rare: Glucose Tolerance Decreased, Urate Crystalluria.Musculoskeletal System
Frequent: Arthralgia, Leg cramps, Myalgia, Myasthenia;
Infrequent: Arthrosis;
Rare: Generalized Spasm.Nervous System
Frequent: Anxiety, Depersonalization, Hypertonia, Hypesthesia, Libido decreased, Nystagmus, Paresthesia, Stupor, Twitching;
Infrequent: Abnormal dreams, Agitation, Apathy, Aphasia, Circumoral paresthesia, Dysarthria, Hallucinations, Hostility, Hyperalgesia, Hyperesthesia, Hyperkinesia, Hypokinesia, Hypotonia, Libido increased, Myoclonus, Neuralgia;
Rare: Addiction, Cerebellar syndrome, Cogwheel rigidity, Coma, Delirium, Delusions, Dysautonomia, Dyskinesia, Dystonia, Encephalopathy, Extrapyramidal syndrome, Guillain Barre syndrome, Hypalgesia, Intracranial hypertension, Manic reaction, Paranoid reaction, Peripheral neuritis, Psychotic depression, Schizophrenic reaction, Torticollis, Trismus.Respiratory System
Rare: Apnea, Atelectasis, Bronchiolitis, Hiccup, Laryngismus, Lung edema, Lung fibrosis, Yawn.Skin and Appendages
Frequent: Pruritus;
Infrequent: Alopecia, Dry skin, Eczema, Hirsutism, Skin ulcer, Urticaria, Vesiculobullous rash;
Rare: Angioedema, Exfoliative dermatitis, Lichenoid dermatitis, Melanosis, Petechial rash, Purpuric rash, Pustular rash, Skin atrophy, Skin necrosis, Skin nodule, Stevens-Johnson syndrome, Subcutaneous nodule.Special senses
Frequent: Conjunctivitis, Diplopia, Otitis media, Tinnitus;
Infrequent: Abnormality of accommodation, Blepharitis, Dry eyes, Eye hemorrhage, Hyperacusis, Photophobia, Retinal edema, Taste loss, Taste perversion;
Rare: Anisocoria, Blindness, Corneal ulcer, Exophthalmos, Extraocular palsy, Iritis, Keratitis, Keratoconjunctivitis, Miosis, Mydriasis, Night blindness, Ophthalmoplegia, Optic atrophy, Papilledema, Parosmia, Ptosis, UveitisUrogenital System
Frequent: Anorgasmia, Impotence, Urinary frequency, Urinary incontinence;
Infrequent: Abnormal ejaculation, Albuminuria, Amenorrhea, Dysmenorrhea, Dysuria, Hematuria, Kidney calculus, Leukorrhea, Menorrhagia, Metrorrhagia, Nephritis, Oliguria, Urinary retention;
Rare: Acute kidney failure, Balanitis, Bladder Neoplasm, Cervicitis, Dyspareunia, Epididymitis, Female lactation, GlomerulitisWarnings
Withdrawal of Antiepileptic Drugs (AEDs)
As with all AEDs, pregabalin should be withdrawn gradually to minimize the potential of increased seizure frequency in patients with seizure disorders. If pregabalin is discontinued this should be done gradually over a minimum of 1 week.
Read more from the fact sheets on Lyrica:
Lyrica Description (http://www.rxlist.com/cgi/generic4/lyrica.htm)
Lyrica Pharmacology (http://www.rxlist.com/cgi/generic4/lyrica_cp.htm)
Lyrica Dosage Information (http://www.rxlist.com/cgi/generic4/lyrica_ids.htm)
Lyrica Side Effects and Drug Interactions (http://www.rxlist.com/cgi/generic4/lyrica_ad.htm)
Lyrica Warnings and Precautions (http://www.rxlist.com/cgi/generic4/lyrica_wcp.htm)
Lyrica Overdose Information (http://www.rxlist.com/cgi/generic4/lyrica_od.htm)
Lyrica Patient Information (http://www.rxlist.com/cgi/generic4/lyrica_pi.htm)